A UNESCO-designated World Heritage site, Lyon — at the confluence of the Rhône and Saône Rivers in France — bears testament to what cultural heights can be achieved over the course of two thousand years. Once the capital of Gaul, a city in the Holy Roman Empire and a silk manufacturing hub, Lyon is a treasure trove of history from its Roman amphitheater to the traboules (medieval passageways). It's also a gastronomic capital where you can grab a seat at a bouchon (family-run bistro) and dine on the city's hearty regional specialties.