Cape Girardeau, positioned on the left bank of the Mississippi, 115 miles south of St. Louis and just above its confluence with the Ohio River, has long been a stopping off point for travelers on the waterways. Notable visitors have included explorers Meriwether Lewis and William Clark, who dropped by in 1803 during their Corps of Discovery expedition west through the Rockies to the Pacific. That warm Missouri welcome continues today when river cruises come calling.