You’re truly in the heart of the Brazilian Amazon in this port, located midway between Belém and Manaus. Although only a fraction of the size of the two cities, Santarém is one of the region's busier export hubs as well as a popular river cruise stop near the confluence of the Amazon and Tapajós rivers. The pristine Tapajós has beautiful blue water and more than 60 miles of sandy beaches. Santarém, founded as a Jesuit colony in the 17th century, is considered one of Brazil’s oldest settlements.