Truth: Not if You Cruise in the United States

America is home to one of the world’s most famous rivers — the Mississippi. There are also the Ohio and Tennessee Rivers in the Midwest and the Columbia and Snake Rivers in the Pacific Northwest. US river cruises visit top destinations like New Orleans, LA; Memphis, TN; St. Louis, MO; Astoria, OR; and Mt. St. Helens, WA, to name a few. The newest itinerary? A seven-night, wine-centric cruise sailing roundtrip from San Francisco with American Queen Voyages.